Plectin protein

Author: ktug

August undefined, 2024

WebbObjectives To assess whether BP patients have autoantibodies targeting plectin, another hemidesmosomal component showing extensive homology to BP230. ... Conclusions Our results indicate that sera from BP patients might contain autoantibodies binding to plectin. Although this protein and BP230 are closely sequence-related, ...

Plectin - Wikipedia

Webb30 aug. 2024 · Moreover, plectin is a scaffolding protein known to bind to the receptor for activated C kinase 1 (RACK1), thus modulating protein kinase C (PKC) signaling … WebbThe PLEC gene provides instructions for making a protein called plectin. This protein is produced in many different tissues in the body, including skin and muscle. Within cells, … bugs on zucchini leaves

Plectin isoform P1b and P1d deficiencies differentially affect

WebbPlectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). … WebbPlectin was expressed in all adult and fetal tissues examined except leukocytes. Only a weak band was obtained from adult brain and thymus. Natsuga et al. (2010) determined that human fibroblasts express 2 different plectin isoforms: a 500-kD full-length protein and a 390-kD protein lacking the rod domain. Webb13 maj 2015 · The faster migration of rodless plectin keratinocytes is not due to altered biochemical properties because, like full-length plectin, rodless plectin is a dimeric protein. Our data demonstrate that rodless plectin can functionally compensate for the loss of full-length plectin in mice. bugs on your eyelashes

Plectin: general overview and appraisal of its potential role as a ...

Plectin: a cytolinker by design - PubMed

Webb30 aug. 2024 · Moreover, plectin is a scaffolding protein known to bind to the receptor for activated C kinase 1 (RACK1), thus modulating protein kinase C (PKC) signaling pathways, and it has been shown to interact with phosphatidylinositol-4,5-biphosphate (PIP2) [ 7 ], integrin α6β4 [ 8 ], and calmodulin [ 9 ], among others. Webb1 dec. 2011 · Author Summary Hemidesmosomes are specialized protein complexes that promote anchorage of the basal keratinocyte cell layer of the epidermis to the underlying dermis. They provide tissue integrity and resistance to mechanical forces. When hemidesmosomes do not function properly, skin blistering ensues in response to … crossfit gyms in missoula mtWebbTo confirm the absence of plectin expression in mutant mice on the protein level, skin and muscle tissue homogenates prepared from mutant and wild-type mice were analyzed by immunoblotting using a rabbit anti-plectin antiserum (Figs. 1D and 2D) and monoclonal antibodies to plectin (data not shown), both immunoreactive with the rod domain of the … bug soother

"Webb4 apr. 2024 · Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, … " - Plectin protein

Plectin protein

Targeted Proteolysis of Plectin Isoform 1a Accounts for ... - PLOS

Webb5 aug. 2024 · The human plectin gene (PLEC) on chromosome 8q24 codes for a 4,684 amino acids large protein whose isoforms [] are key for the functional and structural organization of filamentous cytoskeletal networks, thereby contributing to fundamental biomechanical properties of mechanical stress-bearing tissues [].Plectinopathies thus … Webb13 apr. 2024 · Actin-linked and/or Z-disk-associated cytoskeleton: Plectin, Cortactin, Myozenin, Synaptopodin 2-l, LIM-domain-binding protein 3, Myospryn. Plectin, a cytoskeletal protein that forms physical links between actin, microtubules, and intermediate filaments, exhibited increased phosphorylation at Ser4415 in Obscn …

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Webb21 apr. 2024 · As such, therapeutic targeting of plectin, its protein interactors, and in particular, cancer-specific plectin (CSP), presents an attractive opportunity to impede carcinogenesis directly”. The article reports on plectin’s differential gene and protein expression in cancer, explores its mutational profile, and discusses the current … WebbThe Pathology section contains mRNA and protein expression data from 17 different forms of human cancer. Correlation analysis based on mRNA expression levels of human …

Webb12 apr. 2024 · Stability Test: The thermal stability is described by the loss rate. The loss rate was determinedby accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and noobvious degradation and precipitation were observed. The loss rate is less than 5% within theexpiration date under appropriate storage condition. [SEQUENCE] Webb9 feb. 2024 · Here, we show that plectin, a major intermediate filament-based cytolinker protein, orchestrates cortical cytoskeletal networks in epithelial sheets to support …

Webb30 aug. 2024 · Background Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation, migration, adhesion, and metastasis in melanoma. Plectin, a cytoskeletal … WebbPlectin/S10 domain; This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding. The actual alignment was detected with superfamily member pfam03501:

WebbAdenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene. The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion.Mutations in the APC gene may result in colorectal cancer.. …

Webb30 apr. 1996 · Plectin, a 500-kDa intermediate filament binding protein, has been proposed to provide mechanical strength to cells and tissues by acting as a cross-linking element of the cytoskeleton. crossfit gyms in nampa idahoWebb12 dec. 2005 · To monitor expression of plectin 1 on the protein level and to study its cellular localization, we raised isoform-specific antibodies. Rabbits were immunized with recombinant fusion proteins containing plectin 1-specific sequences, and antibodies highly specific for plectin 1 were obtained by affinity purification. crossfit gyms in naperville ilWebbIf one of the proteins encoded by these genes is malfunctional, this has fundamental effects on the structure and stability of the hairs, since the three proteins are involved in the same metabolic pathway and the subsequent cross-linking of hair proteins is no longer ensured. 19 Clinically, affected children present with shaggy and tousled silvery-blonde … bug soother bug sprayWebbPlectin is a highly preserved structural protein of the cytoskeleton expressed in several cell types, including skeletal muscle, postsynaptic membrane, and skin. Plectin deficiency … bugs on zucchini plantsWebb14 okt. 2008 · Protein names Recommended name Plectin Short names PCN; PLTN Alternative names Hemidesmosomal protein 1 ( HD1) Plectin-1 Gene names Name … crossfit gyms in montgomery alWebb13 jan. 2015 · PLEC:plectin [Gene - OMIM - HGNC] Variant type: single nucleotide variant Cytogenetic location: 8q24.3 Genomic location: Chr8: 143921326 (on Assembly GRCh38) Chr8: 144995494 (on Assembly GRCh37) ... Protein change: R2800H Links: dbSNP: rs6558407 NCBI 1000 Genomes Browser: rs6558407 crossfit gyms in mt pleasant miWebb20 mars 2024 · Plectin is expressed as several protein isoforms in a wide range of cell types and tissues from a single gene located on chromosome 8 in humans (PMID: 8633055, 8698233). Until 2010, this locus was named plectin 1 (symbol PLEC1 in human; Plec1 in mouse and rat) and the gene product had been referred to as "hemidesmosomal … crossfit gyms in new bern nc