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Phgdh cancer

WebSep 1, 2024 · Brain-metastatic cancer cells had increased expression of PHGDH, an enzyme in the serine-synthesis pathway. PHGDH expression was required for proliferation in low-serine conditions in vitro and brain metastasis in vivo. Pharmacologic PHGDH inhibition suppressed brain metastasis, so PHGDH inhibitors may be worth investigating. WebJul 4, 2024 · Together, our results reveal a metabolic homeostasis regulation mediated by a renal UTX-PHGDH-serine axis. Subject terms: Nephrology, Physiology. ... Hubei Cancer Hospital and Union Hospital of Tongji Medical College (approval numbers (2024)16, LLHBCH2024YN-015, and (2024)S196, respectively), all subjects included in the study …

Comprehensive analysis of PHGDH for predicting prognosis and ...

WebJun 4, 2024 · Among the genes identified, PHGDH is in a genomic region of recurrent copy number gain in breast cancer and PHGDH protein levels are elevated in 70% of estrogen receptor-negative breast cancers. PHGDH catalyzes the first step in the serine biosynthesis pathway, and breast cancer cells with high PHGDH expression have increased serine … WebFigure 1 PHGDH is increased in platin-resistant ovarian cancer and predicts poor prognosis of patients with ovarian cancer.(A) PHGDH expression was assessed using Western blot in platin-sensitive (parental) and their platin-resistant (DDP) SKOV3 and A2780 cells. The relative expression was noted under the blots. (B) PHGDH expression was investigated in … swt transport https://marbob.net

In This Issue - American Association for Cancer Research

WebDec 30, 2024 · The levels of Josephin-2 and phosphoglycerate dehydrogenase (PHGDH) were determined using RT-qPCR and western blotting. Cell proliferation, migration and invasion were assessed by CCK-8, colony formation and Transwell. Spheroid-forming assay was performed to assess the cancer stem cell (CSC)-phenotype of HCC cells. WebIdentifying increased PHGDH expression as a resistance mechanism for a variety of cancer therapeutics offers the opportunity to combine PHGDH inhibition with small molecule … WebPHGDH. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. … textron beechcraft

Nuclear PHGDH protects cancer cells from nutrient stress

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Phgdh cancer

Nuclear PHGDH protects cancer cells from nutrient stress

Web研究表明，phgdh在多种人类肿瘤中呈高表达，如黑色素瘤、胰腺癌、宫颈癌和三阴性乳腺癌等。抑制phgdh可降低丝氨酸合成，抑制肿瘤细胞增殖、迁移和侵袭。因此，phgdh抑制剂可以作为治疗癌症的有效策略。 WebApr 13, 2024 · Among those, SLC38A1, MTHFD1, GCSH, and PHGDH were upregulated ... ARP1 and RPMI-8226 cell lines were obtained from Cancer Research Institute, Central South University. OPM2 cell line was obtained ...

Phgdh cancer

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WebDec 7, 2024 · Recent work by Shu et al (2024) unveils a novel, non-canonical function of the de novo serine synthesis pathway enzyme phosphoglycerate dehydrogenase (PHGDH) as … WebApr 25, 2016 · These compounds reduce the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells in culture and in orthotopic xenograft tumors. Surprisingly,...

WebApr 28, 2024 · A model in which PHGDH activity modulates redox homeostasis may reconcile prior studies investigating PHGDH's role in supporting serine-dependent cell anabolism. A major unsolved question in the field is understanding whether cancer cells utilize extracellular serine differently from serine synthesized de novo. WebImportantly, we find that PHGDHhigh breast cancer cell lines are exquisitely sensitive to inhibition of the NAD+ salvage pathway. Further, we find that PHGDH protein levels and those of the rate-limiting… Show more NAD+ is a key metabolic redox cofactor that is regenerated from nicotinamide through the NAD+ salvage pathway.

WebJun 1, 2016 · PHGDH was identified as a predictor for unfavorable prognosis in breast cancer but not in lung cancer, suggesting potential tissue-specific roles for PHGDH. WebNCT-503 is a small molecule 3-phosphoglycerate dehydrogenase (PHGDH) inhibitor (IC50=2.5 uM) that reduces the production of glucose-derived serine in cells and suppress the growth of PHGDH-dependent cancer cells.NCT-503 exhibits EC50 of 8-16 uM for the PHGDH-dependent cell lines; has reasonable aqueous solubility and favorable ADME …

WebHere we find that the loss of phosphoglycerate dehydrogenase (PHGDH) potentiates metastatic dissemination. Specifically, we find that heterogeneous or low PHGDH …

WebJan 3, 2024 · Being the rate-limiting enzyme within the serine biosynthesis pathway, phosphoglycerate dehydrogenase (PHGDH) is abnormally overexpressed in numerous malignant tumor cells and is a promising target for cancer treatment. Here, we report a series of novel PHGDH inhibitors using a focused compound screening and structural … textron beechcraft addressWebNov 14, 2016 · Phosphoglycerate dehydrogenase (PHGDH) is the metabolic enzyme responsible for shunting the glycolytic intermediate 3-phosphoglycerate to the serine synthesis pathway. In breast cancer and several other types of cancer, increased PHGDH expression is associated with patient mortality. sw tucker bridge richmond vaWebMay 9, 2024 · Member the National Cancer Institute for the IMAT and Tumor Biology Study Sections, ... PKCζ represses the expression of two key … textron beechcraft technical support