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Perinuclear dot-like staining pattern

WebJan 1, 2024 · Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma) has a characteristic dot-like paranuclear CK20 staining pattern [16] and the expression of CDX-2 is highly specific in identifying neuroendocrine tumor of intestinal tract origin [28]. As expected, the tumor in our case was negative for these markers. WebWe present a case of EFH with dot-like Golgi pattern perinuclear ALK expression, a previously undescribed staining pattern. We surmised this unique staining pattern could be due to a novel fusion partner, and using FISH, we confirmed a rearrangement of the ALK (2p23) locus. Further investigation with whole transcriptome sequencing led to the ...

Perinuclear dot-like cytokeratin 20 staining in small cell

WebNov 15, 2012 · Studies demonstrate that CD99 positive cells show paranuclear dot-like immunoreactivity in PC [40] [41] [42]. In addition, pancreatic solid-pseudopapillary neoplasms show an exclusive dot-like... WebAug 29, 2024 · This dual stain has 2 additional diagnostic uses: cytoplasmic staining for WT1 is characteristic of melanoma and some sarcomas, 8 and AE1/AE3 demonstrates a weak, perinuclear “dot-like” pattern in small cell carcinoma. 9 In the majority of cases, this stain is sufficient on its own to differentiate mesothelial from epithelial cells, and to … iphone 8 constantly rebooting https://marbob.net

Immunohistochemical and molecular detection of the expression …

WebNov 17, 2024 · Since it is a nuclear stain, INSM1 may be particularly helpful in tumors with severe crush artifact. Up to 90% of SCLCs are also positive for TTF-1 [21, 22]. Cytokeratin stains are weak with a perinuclear dot-like staining pattern . The proliferation index by Ki-67 (MIB-1) is high, usually ranging from 80 to 100% of tumor nuclei . WebSome areas of perinuclear dot-like positivity are seen. (C) Immunostaining with antithyroid transcription factor 1 (anti-TTF-1) in an SCC showing strong nuclear and cytoplasmic staining. (D) Immunostaining with anti-TTF-1 in … WebPseudoverrucous papules and nodules are a skin condition characterized by striking 2– to 8–mm, shiny, smooth, red, moist, flat-topped, round skin lesions in the perianal area of … orange background halloween

Immunohistochemistry for Diagnosis of Metastatic Carcinomas of …

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Perinuclear dot-like staining pattern

Merkel cell carcinoma on the dorsalis pedis with both …

WebMerkel cell tumors are characterized by perinuclear dot-like structures (keratin but- ton) for cytokeratin 20 [10, 11], but these pattern is not uni- versally seen as is true of those in the present case [7]. In humans, small cell carcinoma of the lung often metas- … WebMar 9, 2016 · Thus, the perinuclear, dot-like staining pattern is reliable phenotypic characteristic of FGF23 expression. Similar perinuclear staining patterns of other markers …

Perinuclear dot-like staining pattern

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WebMar 1, 2024 · MUC5AC expression in ALK + cancers was exclusively visualized through cytoplasmic staining (100%), whereas EGFR-mutated cancers showed predominantly perinuclear dot-like patterns (90.5%) and focal cytoplasmic staining (9.5%). MUC2 and MUC6 expression was not detected in either type of lung cancer. WebMay 19, 2015 · The Topo I-like pattern can comprise staining of five subcellular regions: 1) Prominent fine speckled nuclear staining in interphase cells. 2) Consistent strong fine speckled staining of condensed chromatin in mitotic cells. Depending on the serum dilution used, the mitotic chromatin staining may appear homogeneous.

WebThe pattern of immunohistochemical expression of ALK in EFH in the literature thus far describes both granular cytoplasmic staining and nuclear staining. We present a case of … WebBackground: Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, …

WebImmunohistochemistry with desmin: perinuclear dot-like staining (arrow). Source publication An Unusual Presentation of Desmoplastic Small Round Cell Tumour of the … WebApr 12, 2024 · The mechanism associated with dot-like perinuclear CK20 staining, however, remains unknown. CK20 is of significant value as a highly specific marker for Merkel cells …

WebCytokeratin-20 (CK-20) is highly sensitive marker for MCC and it is positive in about 89-100% of cases, demonstrating a characteristic perinuclear dot-like staining pattern in tumor cells. Along with CK-20, MCC often stains positively with low molecular weight cytokeratin (CAM-5), neuron specific enolase (NSE) and synaptophysin.

Web(D) A histologic slide showed cohesive tumor cells with round-shaped nuclei and a fine chromatin pattern (magnification ×200). (E,F) An immunohistochemical study demonstrated a perinuclear and/or dot-like staining pattern for CK20 (E) and a nuclear staining pattern for INSM1 (F). ((E,F), ×400). The inguinal lymph node biopsy was diagnosed as ... iphone 8 cost 2022WebAug 1, 2024 · Positive staining with LCA (CD45) and/or vimentin, but negative staining for S100 and CK, indicates lymphoid lineage, with high sensitivity and specificity for lymphoid malignancies. 7, 8 However, a large percentage of lymphoblastic leukemias are frequently negative for LCA, 9, 10 with unpredictable and frequently negative staining patterns in … orange background for powerpointWebing perinuclear cytokeratin dots is small cell carci-noma. Typically in this tumor, the dots are relative-ly small, and in nearly all cases, these cytokeratin dots are more prominent with … orange background music