WebJan 1, 2024 · Merkel cell carcinoma (primary cutaneous neuroendocrine carcinoma) has a characteristic dot-like paranuclear CK20 staining pattern [16] and the expression of CDX-2 is highly specific in identifying neuroendocrine tumor of intestinal tract origin [28]. As expected, the tumor in our case was negative for these markers. WebWe present a case of EFH with dot-like Golgi pattern perinuclear ALK expression, a previously undescribed staining pattern. We surmised this unique staining pattern could be due to a novel fusion partner, and using FISH, we confirmed a rearrangement of the ALK (2p23) locus. Further investigation with whole transcriptome sequencing led to the ...
Perinuclear dot-like cytokeratin 20 staining in small cell
WebNov 15, 2012 · Studies demonstrate that CD99 positive cells show paranuclear dot-like immunoreactivity in PC [40] [41] [42]. In addition, pancreatic solid-pseudopapillary neoplasms show an exclusive dot-like... WebAug 29, 2024 · This dual stain has 2 additional diagnostic uses: cytoplasmic staining for WT1 is characteristic of melanoma and some sarcomas, 8 and AE1/AE3 demonstrates a weak, perinuclear “dot-like” pattern in small cell carcinoma. 9 In the majority of cases, this stain is sufficient on its own to differentiate mesothelial from epithelial cells, and to … iphone 8 constantly rebooting
Immunohistochemical and molecular detection of the expression …
WebNov 17, 2024 · Since it is a nuclear stain, INSM1 may be particularly helpful in tumors with severe crush artifact. Up to 90% of SCLCs are also positive for TTF-1 [21, 22]. Cytokeratin stains are weak with a perinuclear dot-like staining pattern . The proliferation index by Ki-67 (MIB-1) is high, usually ranging from 80 to 100% of tumor nuclei . WebSome areas of perinuclear dot-like positivity are seen. (C) Immunostaining with antithyroid transcription factor 1 (anti-TTF-1) in an SCC showing strong nuclear and cytoplasmic staining. (D) Immunostaining with anti-TTF-1 in … WebPseudoverrucous papules and nodules are a skin condition characterized by striking 2– to 8–mm, shiny, smooth, red, moist, flat-topped, round skin lesions in the perianal area of … orange background halloween