Megalin function

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August undefined, 2024

Web30 mrt. 2004 · Dent disease is characteristic for the urinary loss of low-molecular-weight proteins and calcium, leading to renal calcification and, in some patients, chronic renal failure. This disorder is caused by loss-of-function mutations in the renal chloride channel gene, CLCN5. The animal model of this disease has demonstrated the possible role of … Web1 nov. 2002 · While megalin is expressed in many epithelial cells, it appears at present that the expression of cubilin is more restricted (for a review see ). The two receptors are co‐localized in the proximal tubule, the small …

Megalin-and cubilin-dependent uptake of albumin.

Web23 jun. 2005 · Megalin is a multifunctional endocytic receptor that is expressed in renal proximal tubules and plays critical roles in the renal uptake of various proteins. It was hypothesized that megalin-dependent endocytosis might play a … WebMegalin is a large multifunctional endocytic clearance receptor for circulating proteins that has been implicated in vitamin D uptake and delivery to the kidney for activation to 1,25 (OH)2 D [62]. Knockout of the megalin gene in mice usually is lethal but the few survivors were characterized as having severe rickets [63]. gazonrollen

LRP2 Gene - GeneCards LRP2 Protein LRP2 Antibody

Web26 jan. 2016 · Impairment of megalin function, even in the early stages of diabetes, has been observed in rat animal models as well as in patients [78–80]. Streptozotocin-induced diabetic rats had decreased protein expression of megalin at the apical membrane of proximal convoluted tubule cells. Web1 nov. 2024 · Megalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors … WebThis study examined whether urinary C-megalin reflects renal function or albuminuria in diabetes. Methods: This was a cross-sectional study involving 1576 patients with type 1 … gazonstart

4036 - Gene ResultLRP2 LDL receptor related protein 2 [ (human)]

Megalin and cubilin: synergistic endocytic receptors in renal …

WebMegalin is an endocytic receptor expressed on the apical surface of several epithelial cells that internalizes a variety of ligands including nutrients, hormones and their carrier … Web1 dec. 2003 · Megalin was first identified by Kerjaschki and Farquhar and later found to be a member of the low-density lipoprotein receptor family, composed of a single-transmembrane domain, a large ectodomain, and a short cytoplasmic tail (10–12).Megalin mediates tubular uptake of low-molecular-weight proteins in the kidney and is also involved in the … gazonor lensWebMegalin is active in the development and function of many parts of the body, including the brain and spinal cord (central nervous system), eyes, ears, lungs, intestine, reproductive … autoalan kauppa ja korjaamotoiminta tes

"WebMegalin, a member of the low density lipoprotein endocytic receptor family, is expressed on the apical surface of thyroid epithelial cells, directly facing the follicle lumen, where … " - Megalin function

Megalin function

Renal Uptake of - Journal of Nuclear Medicine

WebNormal reabsorption of glomerular filtrate proteins probably requires recycling of the endocytic receptors megalin (gp330) and cubilin. Both receptors are located on the … WebMegalin is an endocytic receptor responsible for thyroglobulin (Tg) transcytosis, a process that favors hormone release. Accordingly, megalin KO mice have primary …

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Web31 mrt. 2015 · Besides the kidney, megalin is expressed in many absorptive epithelia, including the neuro-epithelium. There, megalin is thought to participate to RME-associated cell signaling. Failure to uptake ligands at a specific time and/or in a tissue-specific manner during fetal development may provoke the various clinical abnormalities observed in … Web18 feb. 2024 · The functional role of these SBEs and of the SMADs in the repression of megalin expression induced by TGF-ß1, was deciphered using luciferase activation assays. The concomitant overexpression of transcription factors SMAD2 and SMAD3 caused a significant decrease in megalin promoter activity and also of megalin protein, in the …

Webmegalin has a role in thyroid homeostasis with possible implications in thyroid diseases; a binding affinity of disabled homolog 2 mitogen-responsive phosphoprotein interaction … LRP2/megalin functions to mediate endocytosis of ligands leading to degradation in lysosomes or transcytosis. LRP2/megalin can also form complexes with CUBAM , the cubilin and amnionless complex. Those complexes are able to reabsorb several molecules and can be inhibited by sodium maleate. Meer weergeven Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene. Meer weergeven LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of … Meer weergeven LRP2 has been shown to associate with the following proteins in the plasma membrane/cytosol of cells: • CUBAM, • DAB2, Meer weergeven Disfunction in the LRP2-mediated endocytic trafficking and endocytic capacity in the proximal tubule can result in low molecular weight proteinuria, which is a hallmark of many diseases. Mutations in the LRP2 gene are associated with Meer weergeven • Longoni M, Kantarci S, Donnai D, Pober BR (August 2008). "Donnai-Barrow Syndrome". In Adam MP, Mirzaa GM, Pagon RA, … Meer weergeven

Web14 mrt. 2024 · Megalin is well known for its role in the reabsorption of proteins from the ultrafiltrate. Recent studies suggest that megalin also reabsorbs renin and angiotensinogen. Indeed, without megalin urinary renin and angiotensinogen levels massively increase, and even prorenin becomes detectable in urine. Recent Findings WebMegalin and cubilin in proximal tubule protein reabsorption: from experimental models to human disease. Proximal tubule protein uptake is mediated by 2 receptors, megalin …

Web19 jan. 2024 · Thus, substitution of L12-L14 to A12-A14 does not impede megalin’s trafficking to the mitochondria and is not expected to interfere with megalin functions that are independent of STC1 binding ...

Web11 jul. 2014 · Megalin plays a particular key role in the proximal tubular uptake of glomerular-filtered albumin and other low-molecular-weight-proteins. Consistent with this function, megalin knockout mice develop low-molecular-weight proteinuria and albuminuria [ … autoalan kaupan ja korjaamotoiminnan tes 2022Web13 sep. 2024 · There is evolving evidence that megalin is a regulator of the renin-angiotensin system, and contributes to atherosclerosis. This brief review provides … autoalati.rsWeb9 sep. 2024 · The results point to the pro-oncogenic role of the metallothionein-megalin functional axis, which may impact tumor phenotype and behavior. Abstract This study aimed to assess the relationship and possible interactions between metallothioneins (MTs) and megalin (LRP-2) in different grades of oral squamous cell carcinoma (OSCC) and … gazonwekkerWeb1 jan. 2013 · Megalin functions in a complex with the 460-kDa extracellular protein cubilin. Cubilin also binds several plasma proteins, including albumin, but depends on megalin for the endocytosis of cubilin–ligand complexes (19,20). gazonul bvWeb15 mrt. 2024 · Reduction in the functional activity of megalin/cubilin leads to proteinuria, which, if not resolved, can lead to inflammation, fibrosis, kidney injury culminating into cardiovascular diseases, in ... gazonvegerWebMegalin, a membrane-associated endocytic receptor, and its related proteins such as cubilin, the neonatal Fc receptor for IgG, and NaPi-IIa are important in receptors … autoalan kaupan ja korjaamotoiminnan tes 2020Web18 nov. 2024 · The endocytic receptor megalin (LRP2) is a member of the LDLR family expressed in the proximal tubules of the kidney, where it is responsible for binding and endocytosing albumin and other low … gazonstart dcm