Kinetochore protein ndc80
Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 Web26 aug. 2024 · Centromere integrity underlies an essential framework for precise chromosome segregation and epigenetic inheritance. Although centromeric DNA …
Kinetochore protein ndc80
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WebTAI-1 is an Orally Active and Highly Potent Hec1 Inhibitor MedChemExpress TAI-1 is an orally active and highly potent first-in-class Hec1 (Ndc80) inhibitor and disrupts Hec1-Nek2 protein interaction, leads to Nek2 degradation. From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. http://www.stemcell8.cn/forum.php?mod=viewthread&tid=5684
http://genome.cse.ucsc.edu/cgi-bin/hgGene?hgsid=1604222127_uzhuYwVI7yBfSCo4gYPQW8c0c2M8&db=mm39&hgg_gene=ENSMUST00000024851.10&hgg_chrom=chr17&hgg_start=71803094&hgg_end=71833852 Web12 apr. 2024 · Altogether, the authors propose that the absence of Cse4-R143me and -K131me affects the stability of the centromeric nucleosome, which is detrimental in the …
Web11 feb. 2011 · The Ndc80 complex lies at the heart of the kinetochore, a large protein machine that accurately segregates chromosomes during cell division. The Ndc80 … Web26 aug. 2024 · The Ndc80 complex, a crucial microtubule binder, populates each kinetochore with dozens of copies. Whether adjacent Ndc80 complexes cooperate to …
WebID: NDC80_MOUSE DESCRIPTION: RecName: Full=Kinetochore protein NDC80 homolog; AltName: Full=Kinetochore protein Hec1; AltName: Full=Kinetochore-associated protein 2; FUNCTION: Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle …
Ndc80 is one of the proteins of outer kinetochore. It forms a heterotetramer with proteins NUF2, SPC25, and SPC24. This protein complex has microtubule-binding domains. HEC is one of several proteins involved in spindle checkpoint signaling. This surveillance mechanism assures correct segregation of … Meer weergeven Kinetochore protein NDC80 homolog is a protein that in humans is encoded by the NDC80 gene. Meer weergeven NDC80 has been shown to interact with MIS12, NEK2 and PSMC2. Meer weergeven • Chen Y, Sharp ZD, Lee WH (September 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins" Meer weergeven cleveland clinic mohs surgeryWebThe spindle checkpoint : Bubs, Mads, and chromosome-microtubule attachment in budding yeast . Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, February 2005. === Includes bibliographical references. === (cont.) DNA damage response, we hypothesize that the perinuclear pool of Mad proteins may be required for spindle … blwd cuWebVandaag · Co-depletion of Ndc80 and CENP-E, on the other hand, also yielded a significant kinetochore-null phenotype than that observed with the depletion of either of the proteins individually, but weaker than that observed for Ndc80+Aurora B or Ndc80+Spindly co-inhibition (Fig. 5 F, G, and data not shown). cleveland clinic moorgate