Irf8 flox mouse

Author: nyne

August undefined, 2024

WebOct 1, 2024 · The IRF8 FLOX mice (C57BL/6J background) were kindly provided by professor Hongliang Li (Wuhan University, China). The hepatocyte-specific IRF8-knockout mice … WebFigure Legend Snippet: Upregulation of downstream targets of ERK pathway. A. Western Blot analysis of protein extract from normal appearing mucosa obtained from small intestines tissues from LSL-K-RasG12D and Villin-Cre/LSL-K-RasG12D mice. 10 ug of total protein extracts from LSL-K-RasG12D and Villin-Cre/LSL-K-RasG12D were analyzed by Western …

Fas Signaling in Macrophages Promotes Chronicity in K/BxN …

WebAug 1, 2024 · Finally, we assessed skin fibrosis in myeloid cell–specific IRF8 conditional knockout (Irf8 flox /flox; Lyz2 Cre/+) mice and found upregulated mRNA levels of extracellular matrix components and increased bleomycin-induced skin fibrosis. In conclusion, altered IRF8 regulation in monocytes and macrophages may be involved in … WebProduct Specific Information. Description: The V3GYWCH monoclonal antibody reacts with human and mouse interferon regulatory factor 8 (IRF8; ICSBP). IRF8 is a 50 kDa transcription factor that plays a critical role in the development of dendritic cells (DC). Specifically, IRF8 is essential in the development and differentiation of plasmacytoid ... dialight rohs

IRF8 Monoclonal Antibody (V3GYWCH), PE (12-9852-82)

WebIrf8 −/ mice exhibited multiple deficiencies in myeloid and lym-phoid systems, including excessive generation of myeloid cells and diminished Th1 immune responses (37–39) … WebJan 1, 2014 · Here we show that IRF8 is downregulated in both mouse hearts and cardiomyocytes after hypertrophic stress treatment. Moreover, IRF8-deficient mice reveal an aggravated pressure overload-induced hypertrophic response, whereas the opposite effects occur in IRF8-overexpressing mice. WebThe Kynu gene ( NCBI Reference Sequence: NM_027552.2 ; Ensembl: ENSMUSG00000026866 ) is located on mouse chromosome 2. Fourteen exons are identified , with the ATG start codon in exon 2 and the TAG stop codon in exon 14 (Transcript Kynu- 201: ENSMUST00000028223). Exon 3 will be selected as target site. Cas9 and gRNA will … c in set theory

Deletion of IRF8 (Interferon Regulatory Factor 8) …

Transcription factors IRF8 and PU.1 are required for …

WebFeb 7, 2024 · IRF8 is required for the development of lymphoid CD8α + DCs, but nothing is known about its requirement for aortic DCs. We reconstituted lethally irradiated Ldlr–/– … WebIRF8 and IRF1 are transcriptional regulators that play critical roles in the development and function of myeloid cells, including activation of macrophages by proinflammatory signals … dialight revenueWebJun 21, 2024 · IRI was induced in Irf8-deficient mice (Irf8 fl/fl Clec9a cre mice) and control mice (Irf8 fl/fl Clec9a wt mice). (A) mRNA expression of chemokine receptors C-C … cin share

"Web014175 B6.Cg- Irf8 tm1.1Hm /J This Irf8 f floxed targeted mutation strain may be useful in generating conditional mutants for studying B cell differentiation, immunodeficiency … " - Irf8 flox mouse

Irf8 flox mouse

Downregulated IRF8 in Monocytes and Macrophages of

WebMar 8, 2024 · SSc remain unknown. IRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage phenotypes in SSc fibrosis. In this study, we measured IRF8 levels in circulating monocytes of 26 patients with SSc (diffuse cutaneous SSc, WebUpon arrival, some Irf8 f mice were bred with B6.Cg-Tg(Sox2-cre)1Amc/J mice (Stock No. 008454) for germline removal of floxed exon 2. Offspring with pan deletion of floxed exon …

Did you know?

WebDec 11, 2024 · Mice with IRF8 deficiency only in colon epithelial cells (termed IRF8cKO) were created by crossing Irf8-floxed mice with villin-cre mice (Figures S1A and S1B) with the deletion of exon 2 (Figure S1C). As reported in the literature, we observed that IRF8KO mice exhibit elevated levels of CD11b + Gr1 + MDSCs as compared to wild-type (WT) mice. … WebIrf8 cKO mice were generated by crossing Irf8 fl/fl mice with Csf1r cre mice, a monocyte/macrophage targeting Cre driver mice. ... Monocyte Subsets with High Osteoclastogenic Potential...

Web品系描述. 通过在Tnfrsf8基因exon 2两侧分别插入loxP位点。. 该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定细胞类型或组织中敲除Tnfrsf8基因的小鼠模型。. WebDuring our analyses, we also examined littermate mice with a genotype of floxed IRF8 only, PU.1 only, or IRF8/PU.1 heterozygous with or without Mb1-Cre (SI Appendix, Table S1). While Mb1-Cre–mediated PU.1 deletion alone did not affect B cell distribution in the BM, Mb1-Cre–mediated IRF8 deletion alone appeared to induce a moderate reduction ...

WebIRF8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages and thus may be involved in the regulation of macrophage … WebFeb 11, 2024 · Mechanistically, loss of SENP3 increases interferon regulatory factor 8 (IRF8) SUMO3 modification at the K310 amino acid site, which upregulates expression of the nuclear factor of activated T cell c1 (NFATc1) and osteoclastogenesis.

WebSecukinumab (anti-IL-17A) (Cosentyx, AIN457) is a human IgG1κ monoclonal antibody that binds to the protein interleukin (IL)-17A, and is applied for the treatment of psoriasis, ankylosing spondylitis, and psoriatic arthritis. MW=147.9 kDa. Selleck's Secukinumab (anti-IL-17A) has been cited by 2 Publications

WebJun 21, 2024 · We generated a mouse line with Irf8 -deficiency in Clec9a -expressing progenitors and hypothesized that Irf8 -deficiency would deplete cDC1s, which may promote a pro-inflammatory immune response and consequently drive AKI/AKD progression. Materials and Methods Animals c in shell scriptWebInterferon regulatory factor 8 (Irf8) is a transcription factor that negatively regulates osteoclast differentiation and Irf8 global knockout (Irf8 -/-) mice have been shown to have … cinshare log inWebLocomotion in Nkx6.2-null mice (n = 10) was characterized by an increased number of steps during the same period of time compared to control mice (n = 15), without any change in … c in sign language imageWebIRF8 (interferon regulatory factor 8) is a transcriptional activator or repressor. It specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes. … dialight safesite high bayWebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed … cinske serialy na netflixeWebInterferon regulatory factor (IRF) 8 is a transcriptional regulator that is essential for the differentiation and function of monocytes and macrophages, and thus may be involved in the regulation... dialight safesite led area lightWebCreLysMFasflox/flox mice expressed Fas on B and T lym-phocytes isolated from peripheral blood (ref. 10 and data not shown) and the peritoneal cavity (Figure 1A). In contrast, Fas … cin sod new