Fstl1 monocyte

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Webfstl1. sections. tissue brain single cell type tissue cell type pathology disease immune cell blood protein subcellular cell line structure metabolic about. introduction history … WebMar 21, 2024 · FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. These results suggest that FSTL-1 may act on the NLRP3 inflammasome to …

FSTL1 aggravates OVA-induced inflammatory responses by

WebOct 17, 2011 · The monocyte cell line U937, which does not express FSTL1, was transfected with a plasmid encoding FSTL1 and stimulated with phorbol myristate acetate and lipopolysaccharide. Cell supernatants were assayed for IL-6, IL-8, monocyte chemotactic protein 1 (MCP-1), and FSTL1 by enzyme-linked immunosorbent assay. WebOur FSTL1 polyclonal, recombinant monoclonal and monoclonal antibodies are developed in Rabbit, Goat, Mouse and Rat. These antibodies have been verified by Relative expression to confirm specificity to FSTL1. Find the FSTL1 antibody that fits your needs. olympia labcorp

Original research: FSTL1 promotes liver fibrosis by reprogramming ...

WebJun 2, 2024 · FSTL1 is a cardioprotective factor [ 4 ], pro-fibrotic agent [ 5 ], and a bi-directional regulator of tumor based upon the origin of the tumorigenic cell line [ 6 ]. Asthmatic patients express high levels of FSTL1 in plasma and bronchoalveolar lavage fluid (BALF) compared with health subjects [ 7 ]. WebSep 1, 2016 · Conversely, knockdown of FSTL1 significantly reduces the production of IL-6 and monocyte chemotactic protein 1 (MCP-1) induced by TNF-α and IL-17 [24]. Thus, these studies demonstrate that FSTL1 is a pro-inflammatory mediator that might be a target in treating inflammatory diseases, specifically rheumatoid arthritis. WebMar 29, 2024 · Follistatin-like 1 (FSTL1) is a secreted glycoprotein displaying expression changes during development and disease, among which cardiovascular disease, cancer, … olympia lacey washington

Anti-FSTL1 Antibodies Invitrogen - Thermo Fisher Scientific

Follistatin-related protein/follistatin-like 1 evokes an innate …

WebThe FLTS1 transcript can function either as an mRNA that encodes the FLTS1 protein or as a primary microRNA (pri-miRNA) transcript that produces miRNA-198 (MIR198). The FLTS1 protein promotes keratinocyte migration and wound repair, whereas MIR198 downregulates genes required for keratinocyte migration and wound repair ( Sundaram et al., 2013 ). WebFSTL1 reduces transcellular transport of LDL-sized particles and of LDL itself, and inhibits endothelial activation. ... (NF-κB), adhesion molecule expression and monocyte … olympia knee doctorWebDec 10, 2024 · FSTL1 is a potential mediator of inflammation and insulin resistance in obesity. Fstl1 is crucial for elastin expression and deposition in mesenchyme during lung alveologenesis; These results suggest that FSTL-1 may act on the NLRP3 inflammasome to promote IL-1beta secretion from monocytes/macrophages. is andy leaving station 19

"WebNov 15, 2024 · Follistatin-like 1 (FSTL1) has been widely reported as a proinflammatory mediator in different fibrosis-related and inflammatory diseases. Here we show FSTL1 expression to be closely correlated with activated fibroblasts and to be elevated in regenerative, fibrotic, and disease liver states in various mouse models. " - Fstl1 monocyte

Fstl1 monocyte

Follistatin-like 1 in development and human diseases - ResearchGate

WebFeb 8, 2024 · Myeloid- specific FSTL1- knock out (FSTL1 M- OK) mice were constructed to explore the function and mechanism of macrophage FSTL1 in 3 murine models of liver fibrosis induced by carbon tetrachloride injection, bile duct ligation or a methionine-deficient and choline-deficient diet. Results FSTL1 expression was significantly elevated WebWhile cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its ...

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WebJun 1, 2024 · 1. Introduction. Follistatin-like protein 1 (FSTL1) is a glycoprotein first discovered by Prof. Shibanuma from the transforming growth factor (TGF) β-stimulated … WebFeb 9, 2024 · FSTL1 expression was significantly elevated in macrophages from fibrotic livers of both humans and mice. Myeloid-specific FSTL1 deficiency effectively attenuated the progression of liver fibrosis. ... as demonstrated by attenuated infiltration of monocytes/macrophages and neutrophils and decreased expression of proinflammatory …

WebFeb 8, 2024 · demonstrated by attenuated infiltration of monocytes/ macrophages and neutrophils and decreased expression of proinflammatory factors. FSTL1M- OK … WebMar 24, 2024 · The FSTL1 protein was significantly less in lung tissues of Fstl1 +/− mice, and the increased FSTL1 protein after silica treatment was reduced in Fstl1 +/− mice (Fig. 2a).

WebAug 31, 2024 · Follistatin-like protein 1 (Fstl1), a glycoprotein widely expressed in human and mouse tissues, is a tumor suppressor in various cancers and a regulator in macrophage polarization. However, how Fstl1 affects the crosstalk between breast cancer cells and macrophages remains unclear. WebMay 17, 2014 · Follistatin-like protein 1 (FSTL1), a secreted glycoprotein, also named TSC-36 [transforming growth factor (TGF)β 1-stimulated clone 36] or FRP (follistatin-related protein), was originally cloned from the mouse osteoblastic cell line MC3T3-E1 [].FSTL1 is widely expressed in human and mouse tissues, although its expression was found to be …

WebSep 1, 2024 · Our understanding of the mechanisms responsible for the progression of chronic kidney disease (CKD) is incomplete. Microarray analysis of kidneys at 4 and 7 weeks of age in Col4a3-/- mice, a model of progressive nephropathy characterized by proteinuria, interstitial fibrosis, and inflammation, revealed that Follistatin-like-1 (Fstl1) …

WebJul 1, 2024 · Follistatin-like 1 (FSTL1) is a secreted glycoprotein displaying expression changes during development and disease, among which cardiovascular disease, cancer, and arthritis. The cardioprotective... is andy murray knightedWebJun 1, 2024 · Furthermore, FSTL1 is an acidic cysteine-rich secreted protein and a member of the SPARC family based on protein domain similarity [5]. Indeed, FSTL1 binds to disco-interacting protein2 homolog A (DIP2A), which is a receptor for FSTL1 as evidenced by molecular interaction analyses by Ouchi et al. [6]. is andy murray playing tennis nowWebFSTL1, derived from fibroblasts/myofibroblasts in the interstitial compartment of the kidney can signal to kidney tubule cells in a paracrine manner, and contribute directly to the three cardinal processes that contribute to the progression of CKD: fibrosis, inflammation, and … olympia lacey waWebJan 2, 2024 · FSTL1 CD14 TLR4 Innate immunity Rheumatoid arthritis abstract Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-speciﬁc binding nature espe … is andy mccarthy a democratWebJan 28, 2014 · Follistatin-like protein 1 (FSTL-1) is a secreted gp produced mainly by cells of the mesenchymal lineage, such as cardiomyocytes, chondrocytes, fibroblasts, and endotheliocytes 1 - 6. It is not produced by cells of the hematopoietic lineage 2. FSTL-1 was initially cloned from a mouse osteoblast cell line as a TGF-β-inducible gene 7. olympia laminate flooring repairWebJan 28, 2014 · FSTL-1 promotes caspase-1 activation in monocytes and macrophages. Human U937 cells stably transfected with plasmid encoding FSTL1 or a control plasmid … olympia lcd 8110 hyperbolic tangentWebFSTL1. General description of the gene and the encoded protein (s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project. Official gene symbol, which is typically a short form of the gene name, according to HGNC. Full gene name according to HGNC. olympia lcd 6112 tischrechner