Tīmeklis2024. gada 20. maijs · EZH2 expression is higher in SCLC than in any tumor type included in the Cancer Genome Atlas , and preclinical analysis showed that an EZH2 inhibitor augmented chemotherapeutic efficacy and could prevent emergence of acquired chemotherapy resistance in multiple in vivo SCLC patient-derived xenograft … TīmeklisEZH2-overexpressing astrocytes revealed upregulation of the Nestin gene (18). EZH2 was also described to promote SCLC progression through suppression of the TGF-β-smad-ASCL1 pathway (19). We have ...

CDYL promotes the chemoresistance of small cell lung cancer by ... - PubMed

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SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line ...

Tīmeklis2024. gada 13. febr. · We chose to examine whether EZH2 (enhancer of zeste homology 2) could have a role in silencing SLFN11 in SCLC for several reasons: (1) there is evidence for an EZH2 binding site upstream of the first exon of SLFN11 from cell line data reported by the ENCODE project (Gerstein et al., 2012, Wang et al., 2013), … TīmeklisEvidence is presented for the role of EZH2 in the regulation of cell cycle and apoptosis, providing a biological mechanism to explain the tumorigenicity of E zeste homolog 2 … Tīmeklis2024. gada 29. marts · SCLC subsets express specific surface markers, providing potential opportunities for antibody-based targeted therapies. ... Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis. Cancer Cell 31, 286–299. Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, … the ups store dublin ohio