012929 FVB(Cg)-Tg(Dhh-cre)1Mejr/J The Dhh-cre transgene harbors a nuclear-localized Cre recombinase gene under control of the mouse desert hedgehog ( Dhh ) promoter/regulatory regions. These transgenic mice may be useful in generating cre -inducible mutations in Sertoli cell precursors (testes development/male germline), endothelial cells, and Schwann cells of the peripheral nervous system. WebCall the Cheshire Medical Center Patient Portal Concierge at 603-354-5454 ext. 2446. You can also visit the myDH FAQ page.

012929 - Strain Details - The Jackson Laboratory

WebJul 1, 2012 · Generation of transgenic animals. Generation of transgenic mice carrying the Dhh gene regulatory element driving Cre recombinase (Dhh-Cre) has been previously … WebSciatic nerves were dissected from P11 Dhh-Cre + LoxpRosa + (A,B) pups as well as Dhh-Cre − LoxpRosa + (C) littermate controls, processed for bluo-gal staining, and examined by electron microscopy. can diabetics eat granulated sugar

Figures and data in P2RY14 cAMP signaling regulates Schwann

WebFeb 7, 2024 · Dhh-Cre Nf1 fl/fl survival mice were predominantly sacrificed due to neurofibroma-associated morbidity (e.g., paralysis), while sacrifice of Dhh-Cre Nf1 fl/fl Cxcr3-null mice was typically necessitated by dermatitis (n = 3 mice) and abdominal bloating/lethargy associated with malignancies typical of aged C57/Bl6 mice (n = 5 colon … WebThis creates a frameshift upon Cre activity resulting in a null allele, which we confirmed by the absence of Fbxw7 mRNA by RT-PCR (Figure S1A). In all cases, Dhhcre(-);Fbxw7fl/+ and Dhhcre(-);Fbxw7fl/fl siblings were used as controls. We analyzed sciatic nerves by transmission electron microscopy (TEM) and found that at WebJul 1, 2012 · Transgenic mice carrying all 3 transgenes [Dhh-Cre; Nf1 flox /+; Pten flox /+ (Nf1-het/Pten-het)] were interbred to generate both experimental and control cohorts . Complete inactivation of Pten in Schwann cells and/or their precursor cells alone can also contribute to enlarged dorsal root ganglia but at a lower penetrance (Supplementary Fig. … fish only aquarium lighting