Cisplatin induced aki

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August undefined, 2024

WebAug 30, 2024 · Cisplatin-induced AKI is dose dependent and thereby limits the dose of drug that can be used . In comparison, hepatotoxicity can occur only when cisplatin is administered at high doses . Thus, cisplatin-induced AKI is considered one of the major side-effects of cisplatin therapy. Although some procedures including hydration …

Neutrophil membrane engineered HucMSC sEVs alleviate cisplatin-induced …

WebRenal TNF-α expression is increased in a cisplatin-induced nephrotoxic mouse, and cisplatin-induced renal insufficiency and injury can be significantly alleviated by TNF-α inhibition or knockout ... WebSep 2, 2024 · Melatonin alleviates renal dysfunction in sepsis-induced acute kidney injury. 8-week-old mice were treated with melatonin (25 μg/ml) dissolved in drinking water for 14 days. ... Melatonin Attenuates Cisplatin-Induced Acute Kidney Injury in Rats via Induction of Anti-Aging Protein, Klotho. Food Chem. Toxicol. 129, 201–210. … flannel board stories first christmas

Cisplatin nephrotoxicity: new insights and therapeutic implications ...

WebSep 1, 2024 · First, we examined whether cisplatin altered renal iron levels and induced oxidative stress in mice. Cisplatin increased the production of ferrous iron and hydroxyl radical, and they were colocalized in the kidney, suggesting the occurrence of the Fenton reaction (Fig. 1 A–C).Total iron content and TfR and FTH protein expression were … WebMar 13, 2024 · Background Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the … WebJun 17, 2024 · A cisplatin-induced AKI mice model was established by administering 22 mg/kg cisplatin to both WT and Tet2 -KO mice to investigate the role of Tet2. It was observed that the Scr and BUN levels... flannel board stories indians and pilgrims

Emerging Role of Ferroptosis in Acute Kidney Injury - Hindawi

Drug-Induced Acute Kidney Injury : Clinical Journal of the …

WebAug 1, 2024 · A mouse model of cisplatin-induced AKI was established as described previously. After 10 mg/kg cisplatin (Sigma-Aldrich, USA, P4394) intraperitoneal injection for 72 h, Neu-NVs, hucMSC-sEVs, and NEX with the same particle number were administered to the AKI mice by tail vein for 2 consecutive days. WebJan 3, 2024 · Cisplatin nephrotoxicity; Classic Kaposi sarcoma: Clinical features, staging, diagnosis, and treatment; Contrast-associated and contrast-induced acute kidney injury: Clinical features, diagnosis, and management; Crystal-induced acute kidney injury; Dosing of anticancer agents in adults; Drug reaction with eosinophilia and systemic … flannel board stories printables preschoolWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … can salted cashews go bad

"WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney injury (AKI). Patients who develop AKI have an increased risk of mortality and are more likely to develop chronic kidney disease (CKD). " - Cisplatin induced aki

Cisplatin induced aki

Myo-Inositol Supplementation Alleviates Cisplatin-Induced Acute …

Websuggests a role for intracellular GSH in preventing cisplatin-induced nephrotoxicity. The renal oxidized GSH concen-tration was signiﬁcantly increased while GSH/oxidized GSH … WebJan 18, 2024 · Background Early detection and prediction of cisplatin-induced acute kidney injury (Cis-AKI) are essential for the management of patients on chemotherapy with cisplatin. This study aimed to evaluate the performance of a prediction model for Cis-AKI. Methods Japanese patients, who received cisplatin as the first-line chemotherapy at …

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WebCisplatin-induced nephrotoxicity is a major adverse event (AE), and the incident rate is approximately 30%. 1 - 3 Three basic mechanisms lead to cisplatin-induced nephrotoxicity, that is, tubular cell toxicity, renal microvasculature vasoconstriction, and proinflammatory effects. 3 Several factors are associated with increased risk of … WebAug 6, 2014 · A known complication of cisplatin administration is acute kidney injury (AKI). The nephrotoxic effect of cisplatin is cumulative and dose-dependent and often necessitates dose reduction or withdrawal. Recurrent episodes of AKI may result in chronic kidney disease.

WebPrevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis Prevention of Cisplatin-Induced Acute Kidney Injury: A Systematic Review and Meta-Analysis Authors WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the …

WebJan 29, 2024 · Fig. 1: Cisplatin induced Renal injury were alleviated by Ferroptosis inhibitor Ferrostatin-1 (Fer-1). A, B Serum BUN and Cr levels of each group at 48 h and 72 h after cisplatin injection.... WebNational Center for Biotechnology Information

WebCisplatin-induced AKI typically occurs 5–7 days after therapy, whereas dialysis-requiring AKI is uncommon in the absence of concomitant nephrotoxic exposures. AKI typically resolves within a few weeks, but progressive CKD …

WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), … can salted butter be clarifiedWebSep 25, 2015 · Purpose Acute kidney injury (AKI) is a common and serious adverse effect of cisplatin-based chemotherapy. However, traditional markers of kidney function, such as serum creatinine, are suboptimal, because they are not sensitive measures of proximal tubular injury. We aimed to determine whether the new urinary biomarkers such as … flannel board stories templatesWebFeb 24, 2024 · Generally, several factors, such as ischemia, insufficiency of the circulating blood volume, nephrotoxic drugs, and urinary tract obstruction, lead to AKI. Apart from blood purification, there are few effective treatments for AKI. Untreated AKI would continue to cause further damage and is associated with a poor prognosis. flannel board stories preschoolWebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine … can salt go offWebOther pathogenic factors such as FA, oxalate, cisplatin, and gentamicin can also promote the occurrence of Fenton-like chemistry, induce ferroptosis, and lead to AKI. The Fenton-like chemistry can be inhibited by intracellular GPX4, a … can salt give you headachesWebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … flannel board stories about winterWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … can salted paste in the jar go bad