Cisplatin binding
Webcells. Non-DNA binding drugs, such as vinca alkaloids, do not attach to DNA within the surrounding tissue.1 Subsequently, indirect damage occurs immediately in the tissue … Web2.4. Screening and characteristics of AM binding to A549/DDP using Cell‐SELEX. Accurate targeting is the key to improving therapeutic effects. Therefore, we used Cell‐SELEX to …
Cisplatin binding
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WebJul 24, 2024 · The aim of this work is to identify the cisplatin binding sites on human H-chain ferritin. High-resolution X-ray crystallography reveals that cisplatin binds four distinct protein sites, that is, the side chains of His136 and Lys68, the side chain of His105, the side chain of Cys90 and the side chain of Cys102. WebUV/Vis spectroscopy confirms the stoichiometry of binding and shows that cisplatin and iron(III) binding are competitive. The binding of cisplatin has been modelled by using …
WebMar 25, 2024 · Given that apoptosis resistance is one of the causes of the cisplatin resistance of tumor cells, our aim was to determine the relationship between RRS1 and cisplatin resistance in breast cancer cells. Here, we report that RRS1 is associated with cisplatin resistance in breast cancer cells. WebAbstract. The reaction between cisplatin and human serum albumin (HSA) was investigated by X-ray crystallography and crystal structures of the cisplatin/HSA adduct were eventually solved for the first time. Structural …
WebAug 19, 2005 · Binding of cisplatin to proteins reduces urinary excretion of platinum, and causes deposition of platinum in tissues. Binding of cisplatin to proteins and enzymes is generally believed to be the cause of several severe side effects exhibited by these drugs, especially ototoxicity and nephrotoxicity. WebMar 29, 2024 · Cisplatin binds to the copper-binding sites in the N-terminal domain of ATP7B; this binding may be an essential step of cisplatin detoxification involving copper ATPases. COX19 is necessary for the transduction of a SCO1-dependent mitochondrial redox signal that regulates ATP7A-mediated cellular copper efflux.
WebCisplatin is a platinum-based chemotherapeutic that has long since been effective against a variety of solid-cancers, substantially improving the five-year survival rates for cancer patients. Its use has also historically been limited by its adverse drug reactions, or cisplatin-induced toxicities (CITs). Of these reactions, cisplatin-induced nephrotoxicity (CIN), …
WebJun 2, 2016 · Cisplatin is a widely prescribed anticancer drug, which triggers cell death by covalent binding to a broad range of biological molecules. Among cisplatin targets, … high rise apartments airbnbWebNov 20, 2024 · Around 24 h after the administration of cisplatin into the bloodstream, 65–98% of this drug is bound to a variety of different plasma proteins, with the highest fraction bound to HSA [ 15, 16 ]. Cisplatin can bind to and form stable complexes with two interaction sites on an HSA molecule. high rise apartment planWebAug 2, 2016 · Our data reveal unexpected cisplatin binding sites on the protein surface that could have general significance: cisplatin fragments − [Pt (NH 3) 2 Cl] +, − [Pt (NH 3 )Cl 2 ], and − [Pt (NH 3) 2 (OH 2 )] 2+ bind … high rise apartment londonWebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. high rise apartment los angelesWebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic agents can help to design an effective anticancer therapy. Human antigen R (HuR) is an RNA binding protein that binds to the AU-rich element (ARE) of specific mRNA and is … high rise apartments alexandria vaWebThe combination of adenoviruses and chemotherapy agents is a novel approach for human cancer therapeutics. A meticulous analysis between adenovirus and chemotherapeutic … high rise apartment viewWebSep 1, 2024 · To identify proteins that bind to cisplatin, they synthesized two different platinum-agarose conjugates, one with two amino groups and another with two chlorides attached to platinum that are available for protein binding, and conducted pull-down assays using cochlear and kidney cells. high rise apartments auckland