Chitosan osteoarthritis gene delivery
WebChitosan–pDNA nanoparticle characteristics determine the transfection efficacy of gene delivery to human mesenchymal stem cells E Malakooty Poor, M Baghaban Eslaminejad, N Gheibi, F Bagheri, ... Artificial cells, nanomedicine, and biotechnology 42 (6), 376-384 , 2014 WebNov 15, 2024 · (1) Background: Collagen is the main component of the connective tissue, playing an important role in the histological architecture and function of living organisms. Targeted therapy and improved imaging diagnosis can be obtained through collagen-binding nanoparticles that concentrate in the extracellular matrix. (2) Methods: We performed a …
Chitosan osteoarthritis gene delivery
Did you know?
WebFeb 23, 2024 · Keywords: Osteoarthritis, Gene therapy, Chitosan, Hyaluronic acid, Chondroitin sulfate, Growth and differentiation factor-5 (GDF-5) plasmid. 1. ... HA and CHS enabled the non-viral vector itself to have some therapeutic effects on OA, making it much more suitable for delivery of gene therapy treatments for OA. WebJun 6, 2024 · Chitosan is a linear copolymer composed by glucosamine and N -acteyl glucosamine units, via β- (1, 4) linkages, namely 2-amino-2-deoxy-β-d-glucan (Fig. 2 a). Chitosan is the product of the deacetylation reaction of chitin (2-acetamido-2 …
WebOsteoarthritis (OA) is a painful, degenerative and inflammatory disease that affects the entire synovial joints. Nowadays, no cure exists, and the pharmacological treatments … WebJan 28, 2024 · A The optical images of the gelation progress. The mixture of N-chitosan and ADH presented in the sol state at room temperature, and it experienced sol-gel …
WebMar 3, 2006 · All these studies point to the versatility and promise of chitosan as a gene carrier, although only limited in vivo efficacy has been demonstrated. Due to the complex …
WebAug 31, 2024 · Chitosan-based carriers have been recently considered for transporting hydrophobic agents such as chemotherapeutic compounds, therapeutic peptides, and nucleic acids ( e.g. DNA and siRNA) [67], [68].
WebIntroduction. Cartilage injury, a common clinical problem, can be caused by trauma, 1 osteoarthritis, 2 rheumatoid arthritis, 3 and exfoliative chondritis. 4 Articular cartilage is a non-vascular tissue, whose regeneration ability is extremely limited. 5,6 Most believe that the damage of mature articular cartilage is partial or superficial, and cartilage cannot … dynamic energy income series fWebDec 1, 2016 · Efficacy of the combination of CM-cordycepin and HAMA hydrogel as a treatment for OA. Safranin-O staining of cartilage samples 4 weeks (A) and 8 weeks (B) after OA induction. crystal tombstoneWebApr 10, 2024 · Novel hyaluronic acid–chitosan nanoparticles as non-viral gene delivery vectors targeting osteoarthritis. International Journal of Pharmaceutics, 420 (2) (2011) ... Combining hyaluronic acid with chitosan enhances gene delivery. Journal of Nanomaterials (2014), 10.1155/2014/246347. 2014. Article 152. Google Scholar. dynamic energy sensingWebConclusions: These results suggested that HA/CS-CrmA nanoparticles could attenuate cartilage destruction and protect against early OA by inhibiting synovial inflammation via … crystal tomkinsWebNov 28, 2011 · Gene therapy, which treats the causes of osteoarthritis by targeting specific pathological mechanisms, is attracting much attention as a promising new treatment … dynamic engineering and solution bhosariWebChitosan can act itself as a precursor or carrier for medical applications such as drug delivery, gene delivery, and wound healing. With the advancement in science technology, it was clearly observed that the amine groups present in chitosan are responsible for various properties such as antimicrobial activity, stability in a wide pH range ... crystal tomlinson jamaicaWebSep 14, 2024 · Chitosan is a derivation from chitin. Its favorable biological properties including biocompatible, biodegradable, and non-toxicity, make chitosan as a promising drug delivery carrier. In addition, chitosan is a water-soluble polymer which makes the process of preparation easier and milder. dynamic engineering and energy solutions ike