Calsyntenin 1
WebAug 1, 2016 · Calsyntenin-1 has previously been shown to mediate transport of endosomes along microtubules in neurons, through interactions with kinesin light chain-1. Here we demonstrate for the first time, we believe, a similar role for calsyntenin-1 in Huh7 cells, mediating intracellular transport of endosomes. In HCV-infected cells we show that ...
Calsyntenin 1
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WebJun 25, 2014 · Calsyntenin-1 is a transmembrane cargo-docking protein important for kinesin-1-mediated fast transport of membrane-bound organelles that exhibits peak expression levels at postnatal day 7. However, its neuronal function during postnatal development remains unknown. We generated a knock-out mouse to characterize … WebJan 1, 2001 · We termed this protein calsyntenin-1, because it binds synaptic Ca 2+ with its cytoplasmic domain. By binding Ca 2+, calsyntenin-1 may modulate Ca 2+-mediated …
WebJul 9, 2014 · Here we identify a kinesin adaptor, Calsyntenin-1 (Clstn-1), as an essential regulator of axon branching and neuronal compartmentalization in vivo. We use morpholino knockdown and a Clstn-1 mutant to show … WebAug 15, 2012 · Here we characterized the function of calsyntenin-1 in neuronal APP transport using selective immunoisolation of intracellular trafficking organelles, …
WebJun 7, 2006 · Calsyntenin-1 Is Enriched in Axonal Growth Cone Vesicles. The presence of calsyntenin-1–containing organelles in developing axons led us to presume that these … WebNov 9, 2024 · Calsyntenin-1(CLSTN1) plays a critical role in the nervous system, but its relevance in cardiovascular diseases is unknown. We investigated the significance of …
WebApr 1, 2008 · The cytoplasmic region of mammalian calsyntenin-1 binds Ca 2+, and it was proposed that calsyntenins may be involved in proteolysis-dependent modulation of synaptic functions through its Ca 2+-binding capacity (13, 26). Based on this idea, the cytoplasmic region of CASY-1 may be essential for learning in C. elegans.
WebSep 22, 2024 · This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is … book cheap flights to bucharestWebMar 21, 2024 · Entrez Gene Summary for CLSTN1 Gene. This gene is a member of the calsyntenin family, a subset of the cadherin superfamily. The encoded transmembrane protein, also known as alcadein-alpha, is thought to bind to kinesin-1 motors to mediate the axonal anterograde transport of certain types of vesicle. Amyloid precursor protein (APP) … god of hebrew scripturesWebNov 14, 2024 · With matching these two groups of identified proteins, calsyntenin-1 (CLSTN1), clusterin (CLU) and neutrophil gelatinase-associated lipocalin (NGAL) were found highly secreted from both cell … book cheap flights to cairoWebDec 31, 2024 · Calsyntenin-1 directly correlated with global pathological tau burden in FTLD (r 2 =.22; p=0.005) and in “pure FTLD” (r 2 =.17; p=0.02). Conclusion Low CSF levels of the post-synaptic modulator, Calsyntenin-1, is specific to FTLD, particularly in cases with little or no tau pathology and could aid the early diagnosis of FTD and the ... god of hell fire 1960WebJan 1, 2001 · By binding Ca2+, calsyntenin-1 may modulate Ca2+-mediated postsynaptic signals. Proteolytic cleavage of calsyntenin-1 in its extracellular moiety generates a … god of heaven มังงะCalsyntenins (Csts, CLSTN) are type I transmembrane proteins that belong to the cadherin superfamily. Their name comes from their ability to bind calcium. In birds and mammals, they consist of three family members (Cst1, 2 and 3), in nematodes one ortholog (CASY-1, originally CDH11) is known. Cst1 (CLSTN1) was first shown to be predominantly expressed in postsynaptic membranes of ex… book cheap flights to chelmsfordWebCalsyntenin-1 (CST-1; also Alcadein-alpha) is a 140 - 150 kDa member of the Alcadein family of molecules. It is expressed in the ER/Golgi and on the plasma membranes of … book cheap flights to barcelona